AustralieFrV1, Main, Exploration, bibRecord, 005B74

IMWG consensus on maintenance therapy in multiple myeloma

Identifieur interne : 005B74 ( Main/Exploration ); précédent : 005B73; suivant : 005B75

IMWG consensus on maintenance therapy in multiple myeloma

Auteurs : Heinz Ludwig [Autriche] ; Brian G. M. Durie [États-Unis] ; Philip Mccarthy [États-Unis] ; Antonio Palumbo [Italie] ; Jesus San Miguel [Espagne] ; Bart Barlogie [États-Unis] ; Gareth Morgan [Royaume-Uni] ; Pieter Sonneveld [Pays-Bas] ; Andrew Spencer [Australie] ; Kenneth C. Andersen [États-Unis] ; Thierry Facon [France] ; Keith A. Stewart [États-Unis] ; Hermann Einsele [Allemagne] ; Maria-Victoria Mateos [Espagne] ; Pierre Wijermans [Pays-Bas] ; Anders Waage [Norvège] ; Meral Beksac [Turquie] ; Paul G. Richardson [États-Unis] ; Cyrille Hulin [France] ; Ruben Niesvizky [États-Unis] ; Henk Lokhorst [Pays-Bas] ; Ola Landgren [États-Unis] ; P. Leif Bergsagel [États-Unis] ; Robert Orlowski [États-Unis] ; Axel Hinke [Allemagne] ; Michele Cavo [Italie] ; Michel Attal [France]

Source :

Blood [ 0006-4971 ] ; 2012.

RBID : Pascal:12-0187416

Descripteurs français

Pascal (Inist)
- Myélome, Consensus, Traitement entretien, Hématologie.

English descriptors

KwdEn :
- Consensus, Hematology, Maintenance treatment, Myeloma.

Abstract

Maintaining results of successful induction therapy is an important goal in multiple myeloma. Here, members of the International Myeloma Working Group review the relevant data. Thalidomide maintenance therapy after autologous stem cell transplantation improved the quality of response and increased progression-free survival (PFS) significantly in all 6 studies and overall survival (OS) in 3 of them. In elderly patients, 2 trials showed a significant prolongation of PFS, but no improvement in OS. A meta-analysis revealed a significant risk reduction for PFS/eventfree survival and death. The role of thalidomide maintenance after melphalan, prednisone, and thalidomide is not well established. Two trials with lenalidomide maintenance treatment after autologous stem cell transplantation and one study after conventional melphalan, prednisone, and lenalidomide induction therapy showed a significant risk reduction for PFS and an increase in OS in one of the transplant trials. Maintenance therapy with single-agent bortezomib or in combination with thalidomide or prednisone has been studied. One trial revealed a significantly increased OS with a bortezomib-based induction and bortezomib maintenance therapy compared with conventional induction and thalidomide maintenance treatment. Maintenance treatment can be associated with significant side effects, and none of the drugs evaluated is approved for maintenance therapy. Treatment decisions for individual patients must balance potential benefits and risks carefully, as a widely agreed-on standard is not established.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321864

Affiliations:

Le document en format XML

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<author><name sortKey="Lokhorst, Henk" sort="Lokhorst, Henk" uniqKey="Lokhorst H" first="Henk" last="Lokhorst">Henk Lokhorst</name>
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<author><name sortKey="Bergsagel, P Leif" sort="Bergsagel, P Leif" uniqKey="Bergsagel P" first="P. Leif" last="Bergsagel">P. Leif Bergsagel</name>
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<placeName><region type="region">Occitanie (région administrative)</region>
<region type="old region">Midi-Pyrénées</region>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">IMWG consensus on maintenance therapy in multiple myeloma</title>
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<s2>Vienna</s2>
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<s2>Los Angeles, CA</s2>
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<sZ>2 aut.</sZ>
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<s2>Buffalo, NY</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
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<country>États-Unis</country>
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</affiliation>
</author>
<author><name sortKey="Palumbo, Antonio" sort="Palumbo, Antonio" uniqKey="Palumbo A" first="Antonio" last="Palumbo">Antonio Palumbo</name>
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<s2>Torino</s2>
<s3>ITA</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<placeName><settlement type="city">Turin</settlement>
<region type="région" nuts="2">Piémont</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Miguel, Jesus San" sort="Miguel, Jesus San" uniqKey="Miguel J" first="Jesus San" last="Miguel">Jesus San Miguel</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>University Hospital of Salamanca</s1>
<s2>Salamanca</s2>
<s3>ESP</s3>
<sZ>5 aut.</sZ>
<sZ>14 aut.</sZ>
</inist:fA14>
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<wicri:noRegion>University Hospital of Salamanca</wicri:noRegion>
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<author><name sortKey="Waage, Anders" sort="Waage, Anders" uniqKey="Waage A" first="Anders" last="Waage">Anders Waage</name>
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<author><name sortKey="Richardson, Paul G" sort="Richardson, Paul G" uniqKey="Richardson P" first="Paul G." last="Richardson">Paul G. Richardson</name>
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<author><name sortKey="Hulin, Cyrille" sort="Hulin, Cyrille" uniqKey="Hulin C" first="Cyrille" last="Hulin">Cyrille Hulin</name>
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<author><name sortKey="Niesvizky, Ruben" sort="Niesvizky, Ruben" uniqKey="Niesvizky R" first="Ruben" last="Niesvizky">Ruben Niesvizky</name>
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<author><name sortKey="Lokhorst, Henk" sort="Lokhorst, Henk" uniqKey="Lokhorst H" first="Henk" last="Lokhorst">Henk Lokhorst</name>
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<country>Pays-Bas</country>
<placeName><settlement type="city">Utrecht</settlement>
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</author>
<author><name sortKey="Landgren, Ola" sort="Landgren, Ola" uniqKey="Landgren O" first="Ola" last="Landgren">Ola Landgren</name>
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<author><name sortKey="Bergsagel, P Leif" sort="Bergsagel, P Leif" uniqKey="Bergsagel P" first="P. Leif" last="Bergsagel">P. Leif Bergsagel</name>
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<author><name sortKey="Orlowski, Robert" sort="Orlowski, Robert" uniqKey="Orlowski R" first="Robert" last="Orlowski">Robert Orlowski</name>
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</affiliation>
</author>
<author><name sortKey="Cavo, Michele" sort="Cavo, Michele" uniqKey="Cavo M" first="Michele" last="Cavo">Michele Cavo</name>
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<s2>Bologna</s2>
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<author><name sortKey="Attal, Michel" sort="Attal, Michel" uniqKey="Attal M" first="Michel" last="Attal">Michel Attal</name>
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<series><title level="j" type="main">Blood</title>
<title level="j" type="abbreviated">Blood</title>
<idno type="ISSN">0006-4971</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
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<seriesStmt><title level="j" type="main">Blood</title>
<title level="j" type="abbreviated">Blood</title>
<idno type="ISSN">0006-4971</idno>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Consensus</term>
<term>Hematology</term>
<term>Maintenance treatment</term>
<term>Myeloma</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Myélome</term>
<term>Consensus</term>
<term>Traitement entretien</term>
<term>Hématologie</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Maintaining results of successful induction therapy is an important goal in multiple myeloma. Here, members of the International Myeloma Working Group review the relevant data. Thalidomide maintenance therapy after autologous stem cell transplantation improved the quality of response and increased progression-free survival (PFS) significantly in all 6 studies and overall survival (OS) in 3 of them. In elderly patients, 2 trials showed a significant prolongation of PFS, but no improvement in OS. A meta-analysis revealed a significant risk reduction for PFS/eventfree survival and death. The role of thalidomide maintenance after melphalan, prednisone, and thalidomide is not well established. Two trials with lenalidomide maintenance treatment after autologous stem cell transplantation and one study after conventional melphalan, prednisone, and lenalidomide induction therapy showed a significant risk reduction for PFS and an increase in OS in one of the transplant trials. Maintenance therapy with single-agent bortezomib or in combination with thalidomide or prednisone has been studied. One trial revealed a significantly increased OS with a bortezomib-based induction and bortezomib maintenance therapy compared with conventional induction and thalidomide maintenance treatment. Maintenance treatment can be associated with significant side effects, and none of the drugs evaluated is approved for maintenance therapy. Treatment decisions for individual patients must balance potential benefits and risks carefully, as a widely agreed-on standard is not established.</div>
</front>
</TEI>
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<li>Rotterdam</li>
<li>Toulouse</li>
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<tree><country name="Autriche"><region name="Vienne (Autriche)"><name sortKey="Ludwig, Heinz" sort="Ludwig, Heinz" uniqKey="Ludwig H" first="Heinz" last="Ludwig">Heinz Ludwig</name>
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<name sortKey="Bergsagel, P Leif" sort="Bergsagel, P Leif" uniqKey="Bergsagel P" first="P. Leif" last="Bergsagel">P. Leif Bergsagel</name>
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</country>
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</region>
<name sortKey="Lokhorst, Henk" sort="Lokhorst, Henk" uniqKey="Lokhorst H" first="Henk" last="Lokhorst">Henk Lokhorst</name>
<name sortKey="Wijermans, Pierre" sort="Wijermans, Pierre" uniqKey="Wijermans P" first="Pierre" last="Wijermans">Pierre Wijermans</name>
</country>
<country name="Australie"><noRegion><name sortKey="Spencer, Andrew" sort="Spencer, Andrew" uniqKey="Spencer A" first="Andrew" last="Spencer">Andrew Spencer</name>
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</country>
<country name="France"><region name="Hauts-de-France"><name sortKey="Facon, Thierry" sort="Facon, Thierry" uniqKey="Facon T" first="Thierry" last="Facon">Thierry Facon</name>
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<name sortKey="Hulin, Cyrille" sort="Hulin, Cyrille" uniqKey="Hulin C" first="Cyrille" last="Hulin">Cyrille Hulin</name>
</country>
<country name="Allemagne"><region name="Bavière"><name sortKey="Einsele, Hermann" sort="Einsele, Hermann" uniqKey="Einsele H" first="Hermann" last="Einsele">Hermann Einsele</name>
</region>
<name sortKey="Hinke, Axel" sort="Hinke, Axel" uniqKey="Hinke A" first="Axel" last="Hinke">Axel Hinke</name>
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<country name="Norvège"><region name="Trøndelag"><name sortKey="Waage, Anders" sort="Waage, Anders" uniqKey="Waage A" first="Anders" last="Waage">Anders Waage</name>
</region>
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<country name="Turquie"><noRegion><name sortKey="Beksac, Meral" sort="Beksac, Meral" uniqKey="Beksac M" first="Meral" last="Beksac">Meral Beksac</name>
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</record>

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IMWG consensus on maintenance therapy in multiple myeloma

IMWG consensus on maintenance therapy in multiple myeloma

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